Studies on Succinate Dehydrogenase
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چکیده
منابع مشابه
Studies on Succinate Dehydrogenase
1. Succinate dehydrogenase flavocoenzyme (“SD-flavin”), previously shown to be an SOLsubstituted riboflavin derivative containing a tertiary nitrogen homoconjugated to the flavin nucleus, was subjected to further hydrolysis and to reduction under acid conditions. Both conditions resulted in the liberation of 1 mole of histidine per mole of flavin. This proves histidine to be the covalent link b...
متن کاملStudies on the binding of carboxin analogs to succinate dehydrogenase.
Carboxin (5,6-dihydro-2-methyl-l,4-oxathiin-3-carboxanilide) and a number of other carboxanilides are known to be potent inhibitors of succinate oxidation in membrane preparations from animal tissues, fungi, and bacteria, acting at the succinate dehydrogenase-coenzyme Q junction. The kinetics and the maximal extent of inhibition of succinate oxidation by carboxanilides and by thenoyltrifluoroac...
متن کاملSingle motoneuron succinate dehydrogenase activity.
We have developed a quantitative histochemical assay for measurement of succinate dehydrogenase (SDH) activity in single motoneurons. A computer image processing system was used to quantify the histochemical enzyme reaction product and to follow the time course of the reaction. The optimal concentration for each of the ingredients of the incubation medium for the SDH reaction was determined and...
متن کاملStudies on succinate dehydrogenase. Effect of monoethyl oxaloacetate, acetylene dicarboxylate, and thyroxine.
Our current studies on enzymatic mechanism and control have included consideration of the action of various types of inhibitors for the enzyme, succinate dehydrogenase (1). Interest in the succinate system stems from (a) its key role in cellular aerobic processes; and (b) the possibilities of investigation of mechanism and the action of inhibitors, partly from the point of view of an earlier in...
متن کاملStudies on succinate dehydrogenase. 13. Reversible activation of the mammalian enzyme.
Mammalian succinate dehydrogenase exists in unactivated and activated states. Transition of the unactivated enzyme to the activated form appears to be a conformation change initiated by combination of the protein with substrates or competitive inhibitors and results in a many-fold increase in catalytic activity. This activation has now been shown to be reversible on removal of the bound activat...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45016-3